Arcturus COVID-19 Vaccine to Benefit from Duke-NUS Genetic Correlation System
Duke-NUS, the Company’s partner, developed a process to track genetic changes and their correlations that augment testing of vaccines. There are specific gene changes that correlate directly with efficacy, particularly the level of neutralizing antibody titers. There are also specific gene changes that correlate with safety-related adverse events, such as headache and fever. Prior studies have shown these changes correlate with longer term outcomes. These gene expression changes can be measured within the first 5 days following vaccination and the data may also guide dose selection.
“The data generated from the Duke-NUS system gives us the ability to more efficiently select the dose and help streamline our vaccine development program, potentially accelerating our timeline,” said Pad Chivukula, Ph.D., Chief Scientific Officer of Arcturus.
Arcturus’ COVID-19 vaccine, LUNAR-COV19, is based on its STARR™ and LUNAR® technologies. For more information, please contact Arcturus by email at Vax@ArcturusRx.com or visit our website www.ArcturusRx.com
Founded in 2013 and based in
Duke-NUS is Singapore’s flagship graduate entry medical school, established in 2005 with a strategic, government-led partnership between two world-class institutions: Duke University School of Medicine and the National University of Singapore (NUS). Through an innovative curriculum, students at Duke-NUS are nurtured to become multi-faceted ‘Clinicians Plus’ poised to steer the healthcare and biomedical ecosystem in Singapore and beyond. A leader in ground-breaking research and translational innovation, Duke-NUS has gained international renown through its five signature research programmes and eight centres. The enduring impact of its discoveries is amplified by its successful Academic Medicine partnership with Singapore Health Services (SingHealth), Singapore’s largest healthcare group. This strategic alliance has spawned 15 Academic Clinical Programmes, which harness multi-disciplinary research and education to transform medicine and improve lives. For more information, please visit https://www.duke-nus.edu.sg/
Forward Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. Any statements, other than statements of historical fact included in this press release, including those regarding strategy, future operations, collaborations, the likelihood of success of the Company’s Coronavirus (COVID-19) vaccine or other products, the status of preclinical and clinical development programs and the planned initiation of clinical trials are forward-looking statements. Arcturus may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in any forward-looking statements such as the foregoing and you should not place undue reliance on such forward-looking statements. Such statements are based on management’s current expectations and involve risks and uncertainties, including those discussed under the heading "Risk Factors" in Arcturus’ Annual Report on Form 10-K for the fiscal year ended
Source: Arcturus Therapeutics Holdings Inc.